Research

Hormonal

Higher levels of even-chain saturated fatty acids (myristic, palmitic, and stearic acid) in plasma phospholipids are positively associated with an increased risk of incident type 2 diabetes, whereas higher levels of odd-chain (pentadecanoic, heptadecanoic) and long-chain (arachidic, behenic, tricosanoic, lignoceric) saturated fatty acids are inversely associated with type 2 diabetes risk.

Stop treating all saturated fats as the same enemy. The type of fat matters significantly for diabetes risk. High levels of even-chain fats (like palmitic and stearic acid, often linked to processed foods and animal fats) are associated with higher diabetes risk. Conversely, odd-chain fats (like pentadecanoic and heptadecanoic acid, biomarkers for dairy fat) and long-chain fats are associated with lower risk. Focus on the quality and source of your fats rather than just minimizing total saturated fat intake.

StrongQualifiesHIGH confidence
Even-chain SFAs that were measured (14:0 [myristic acid], 16:0 [palmitic acid], and 18:0 [stearic acid]) were positively associated with incident type 2 diabetes... By contrast, measured odd-chain SFAs (15:0 [pentadecanoic acid] and 17:0 [heptadecanoic acid]) were inversely associated with incident type 2 diabetes... as were measured longer-chain SFAs (20:0 [arachidic acid], 22:0 [behenic acid], 23:0 [tricosanoic acid], and 24:0 [lignoceric acid])
Nita G. Forouhi et al. · The Lancet Diabetes & Endocrinology · 2014

Why this rating

Large-scale prospective case-cohort study (EPIC-InterAct) with 12,132 incident cases and objective biomarker measurement (gas chromatography) minimizes recall bias.

Source

Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study

Nita G. Forouhi et al. · The Lancet Diabetes & Endocrinology · 2014

DOI 10.1016/s2213-8587(14)70146-9

cohort · n=27296Cited 553×
Read the paper
DOI resolved against Crossref · corpus check 2026-06-10

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