Research
Macro partitioning
Visceral adipose tissue (VAT) is a stronger independent risk factor for type 2 diabetes in women than in men, making waist circumference a more reliable predictor of risk in women.
For women, where you store fat matters more than your total weight. Visceral fat (around your organs) is a much stronger predictor of diabetes than BMI. Focus on reducing waist circumference through lifestyle changes, as this visceral fat drives insulin resistance more significantly in women than in men.
GoodSupportsHIGH confidence
a GWAS confirmed VAT as a stronger independent type 2 diabetes risk factor in women than in men (OR 7.3 vs 2.5)... waist circumference indicates visceral adipose tissue (VAT) more accurately than BMI in women
Why this rating
Supported by GWAS and Mendelian randomization analysis.
Source
Sex differences in type 2 diabetes
Alexandra Kautzky‐Willer et al. · Diabetologia · 2023
DOI 10.1007/s00125-023-05891-x
narrative_reviewCited 552×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Gestational diabetes mellitus (GDM) is the most prominent independent risk factor for the progression to type 2 diabetes in women, increasing the relative risk by approximately 8.3-fold.Strong
- Women with type 2 diabetes face a significantly higher relative risk of cardiovascular disease and mortality compared to men, despite often being diagnosed at a lower body mass index and younger age.Good
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