Hormonal
Semaglutide increases the risk of adverse events, serious adverse events, and discontinuation due to adverse events compared to placebo, primarily driven by gastrointestinal reactions (nausea, diarrhea).
Be aware that semaglutide increases the risk of gastrointestinal side effects like nausea and diarrhea, which can lead to stopping the medication. These side effects are usually temporary and mild to moderate. The risk of discontinuation is higher than with a placebo, so monitoring and managing these symptoms is important for long-term success.
semaglutide increased the incidences of AEs, SAEs, and DAEs compared with placebo, especially DAEs, with statistically significant differences (AEs, RR: 1.10; 95% CI: 1.05 to 1.16; p ˂ 0.00001; SAEs, RR: 1.34; 95% CI: 1.10 to 1.65; p ˂ 0.00001; DAEs, RR: 2.29; 95% CI: 1.74 to 3.01; p ˂ 0.00001)... the incidences of nausea and diarrhea were significantly higher in semaglutide than that in placebo
Why this rating
Meta-analysis of 8 RCTs.
Source
Efficacy and safety of semaglutide on weight loss in obese or overweight patients without diabetes: A systematic review and meta-analysis of randomized controlled trials
Xueqin Gao et al. · Frontiers in Pharmacology · 2022
DOI 10.3389/fphar.2022.935823
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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