Research
Mixed
Obesity and type 2 diabetes share a pathogenesis involving nutrient excess, inflammation, and mitochondrial dysfunction, leading to insulin resistance and beta-cell failure.
Type 2 diabetes in obesity is driven by cellular stress from excess nutrients, causing inflammation and mitochondrial issues. Managing weight reduces this cellular stress, improving insulin sensitivity and beta-cell function.
StrongSupportsVERY_HIGH confidence
Obesity-induced metabolic impairment can favor insulin resistance on the one hand and progressive beta-cell dysfunction on the other... a vicious cycle arises whereby obesity-induced nutrient excess triggers inflammatory responses that cause insulin resistance
Why this rating
Consensus of 32 experts on pathophysiology.
Source
Obesity and Type 2 Diabetes: What Can Be Unified and What Needs to Be Individualized?
Robert H. Eckel et al. · The Journal of Clinical Endocrinology & Metabolism · 2011
narrative_reviewCited 549×
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