Research
Hormonal
Autophagy induction, particularly macroautophagy, is necessary for lifespan extension by Dietary Restriction and reduced IIS, and pharmacological induction (e.g., rapamycin) can increase longevity.
Inducing autophagy, either through Dietary Restriction or pharmacological agents like rapamycin, extends lifespan. Rapamycin treatment in mice at 600 days significantly increased longevity, suggesting that enhancing cellular cleanup mechanisms is a viable strategy for promoting healthspan.
GoodSupportsHIGH confidence
Macroautophagy is also required for DR-induced longevity... The application of rapamycin, a natural inhibitor of mTOR, to mice at a relatively late age (600 days) significantly increased longevity.
Why this rating
Strong evidence in C. elegans and mice; rapamycin effect is profound.
Source
Aging as an Event of Proteostasis Collapse
Rebecca C. Taylor et al. · Cold Spring Harbor Perspectives in Biology · 2011
DOI 10.1101/cshperspect.a004440
narrative_reviewCited 549×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Reduction of dietary intake (Dietary Restriction) extends lifespan by modulating the proteostasis machinery, specifically by reducing translation rates and enhancing autophagy, thereby preventing the accumulation of misfolded proteins.Good
- Reduced Insulin/IGF-1 Signaling (IIS) extends lifespan by allowing transcription factors like DAF-16 and HSF-1 to enter the nucleus and activate proteostasis genes, including chaperones and autophagy components.Good
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