Research
Hormonal
24 hours of wakefulness reduces the amplitude of daily metabolic rhythms (cosinor amplitude) for the majority of metabolites, particularly those that peak during the day.
Staying awake for 24 hours flattens the natural daily ups and downs of your metabolism. This means your body's normal timing for processing nutrients and hormones gets disrupted, which can affect how you feel and perform.
GoodSupportsHIGH confidence
The majority of these metabolites (n = 66; 85%) exhibited reduced amplitude during 24 h of wakefulness. For the metabolites that peaked during the day (n = 67; 86%), most (n = 63; 94%) exhibited a reduction in amplitude during the 24 h of wakefulness.
Why this rating
Robust statistical analysis (cosinor) of 171 metabolites.
Source
Effect of sleep deprivation on the human metabolome
Sarah K. Davies et al. · Proceedings of the National Academy of Sciences · 2014
DOI 10.1073/pnas.1402663111
crossover · n=12Cited 535×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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