Macro partitioning
Carriers of the TM6SF2 E167K genetic variant have a significantly reduced risk of cardiovascular events (myocardial infarction and stroke) and carotid atherosclerosis due to lower circulating levels of atherogenic lipoproteins.
If you carry the TM6SF2 E167K variant, your body naturally keeps blood cholesterol lower by storing more fat in your liver. This genetic trait significantly lowers your risk of heart attacks and strokes, even if you have fatty liver. You should prioritize cardiovascular health monitoring, but the genetic risk for heart disease is actually reduced.
In the SOS cohort, E167K carriers had higher alanine aminotransferase ALT and lower lipid levels (P < 0.05), as well as a lower incidence of cardiovascular events (hazard ratio: 0.61; 95% CI: 0.39-0.95).
Why this rating
Large prospective cohort (n=1,819) with long-term follow-up (median 14 years) and objective clinical endpoints.
Source
Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease
Paola Dongiovanni et al. · Hepatology · 2014
DOI 10.1002/hep.27490
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