Research
Hormonal
Elevated circulating 2-AG levels in visceral obesity are negatively correlated with insulin sensitivity, as measured by glucose infusion rate during euglycemic-hyperinsulinemic clamp, independent of total body fat mass.
High levels of 2-AG in your blood are linked to insulin resistance, meaning your body struggles to use insulin effectively to manage blood sugar. This link exists even when you account for how much fat you have, suggesting 2-AG plays a direct role in metabolic dysfunction.
GoodSupportsHIGH confidence
Circulating 2-AG... was negatively correlated to glucose infusion rate during clamp (r = 0.39, P = 0.009)... The negative correlation between glucose infusion rate and 2-AG was still significant after adjusting the glucose infusion rate for visceral fat area, BMI, or percent body fat.
Why this rating
Gold-standard measurement of insulin sensitivity (clamp) with multivariate adjustment.
Source
Dysregulation of the Peripheral and Adipose Tissue Endocannabinoid System in Human Abdominal Obesity
Matthias Blüher et al. · Diabetes · 2006
DOI 10.2337/db06-0812
cross_sectional · n=60Cited 527×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- In human abdominal (visceral) obesity, circulating levels of the endocannabinoid 2-AG are significantly elevated and correlate with visceral fat mass, serving as a critical correlate of peripheral endocannabinoid system dysregulation.Good
- In visceral adipose tissue of obese individuals, the expression of the CB1 receptor and the degrading enzyme FAAH is downregulated, creating a negative-feedback loop that sustains high local endocannabinoid activity.Good
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