Hormonal
Chronic inflammation impairs muscle regeneration by disrupting the transition of satellite cells from proliferation to differentiation, often leading to fibrosis and reduced muscle quality.
When you injure your muscle, some inflammation is necessary for it to heal properly. Chronic, long-term inflammation (from disease or overuse) is what stops repair and causes scarring. Focus on treating the underlying chronic condition rather than just masking acute pain with anti-inflammatories, as the body needs the initial inflammatory signal to start regeneration.
Chronic injury and proinflammatory cytokines due to tumor progression could be responsible for differentiation program failure... these latter ones actually contribute to fibrosis in mdx mice, leading to pathogenic effects in MDs.
Why this rating
Supported by multiple experimental models and some clinical observations, though human data is noted as lacking in some areas.
Source
Role of Inflammation in Muscle Homeostasis and Myogenesis
Domiziana Costamagna et al. · Mediators of Inflammation · 2015
DOI 10.1155/2015/805172
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This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →