Hormonal
Weekly subcutaneous VK2735, a GIP/GLP-1 receptor dual agonist, produces significant, dose-dependent weight loss in adults with obesity or overweight (≥1 comorbidity) over 13 weeks, with the 15 mg dose achieving a mean 14.7% reduction.
Take VK2735 once weekly as prescribed. Start with the lowest dose (2.5 mg) and follow the titration schedule to minimize side effects. Combine with a 500 kcal daily caloric deficit and 150 minutes of exercise per week for best results. Expect significant weight loss (up to 14.7% at 15 mg) within 13 weeks, with side effects like nausea typically subsiding after the titration phase.
Mean weight reduction with active treatment ranged from 9.2 kg (2.5 mg dose) to 14.6 kg (15 mg dose), corresponding to 9.1% and 14.7% weight reductions, respectively; the placebo group had a 1.8 kg (1.7%) reduction.
Why this rating
Phase 2, randomized, double-blind, placebo-controlled trial with 176 participants; robust design but limited duration (13 weeks).
Source
Weekly Subcutaneous <scp>VK2735</scp> , a <scp>GIP</scp> / <scp>GLP</scp> ‐1 Receptor Dual Agonist, for Weight Management: Phase 2, Randomized, 13‐Week <scp>VENTURE</scp> Study
Harold E. Bays et al. · Obesity · 2026
DOI 10.1002/oby.70106
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