Research
Hormonal
RAAS blockade with ACE inhibitors or ARBs reduces proteinuria and slows the progression to end-stage renal disease in obese patients with proteinuria.
Obese patients with proteinuria benefit significantly from ACE inhibitors like ramipril, which can greatly reduce the risk of kidney failure.
GoodSupportsHIGH confidence
In the Ramipril in Non-Diabetic Renal Failure Trial, obesity predicted an increased incidence of adverse renal outcomes including ESRD, but treatment with the ACEI ramipril attenuated this increased risk.
Why this rating
Supported by clinical trials.
Source
Obesity, hypertension, and chronic kidney disease
John E. Hall et al. · International Journal of Nephrology and Renovascular Disease · 2014
DOI 10.2147/ijnrd.s39739
narrative_reviewCited 516×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Obesity causes hypertension and chronic kidney disease through multiple mechanisms including increased renal tubular sodium reabsorption, sympathetic nervous system activation, RAAS activation, and physical compression of the kidneys by visceral fat.Good
- Weight loss interventions, including caloric restriction and increased physical activity, are effective in lowering blood pressure and reducing proteinuria in obese individuals, though long-term maintenance may be difficult.Good
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