Hormonal
Weight reduction improves insulin sensitivity and reduces hepatic VLDL-triglyceride production rates, supporting a mechanism where insulin resistance drives hypertriglyceridemia.
High insulin levels drive high triglycerides by telling the liver to produce more fat-carrying particles. Losing weight reduces this insulin drive, allowing the liver to produce fewer triglycerides. This suggests that managing insulin sensitivity is key to managing blood fats.
These subjects demonstrated significant decreases after weight reduction in both degree of insulin resistance (33% decrease) and VLDL-TG production rates (40% decrease).
Why this rating
Measured in a subgroup (10-13 subjects) using rigorous metabolic clamp techniques, providing high-quality mechanistic data.
Source
Effects of Weight Reduction on Obesity STUDIES OF LIPID AND CARBOHYDRATE METABOLISM IN NORMAL AND HYPERLIPOPROTEINEMIC SUBJECTS
Jerrold M. Olefsky et al. · Journal of Clinical Investigation · 1974
DOI 10.1172/jci107560
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