Research

Adherence

For individuals with obesity and prediabetes who fail to achieve early weight loss (<2.5% at 4 weeks), adding exercise counseling or time-restricted eating (TRE) counseling does not significantly improve weight loss or glycemic outcomes compared to continuing the initial diet alone.

If you are not losing weight in the first month of a diet, simply adding more exercise counseling or trying a new eating window might not be enough. You may need more intensive support, such as provided meals or supervised exercise, rather than just advice.

GoodRefutesHIGH confidence
Among nonresponders, assignment to second-stage interventions of TRE or exercise did not differ significantly affect changes in any study outcomes, and less weight loss was achieved among early nonresponders compared with responders despite the addition of TRE or exercise.
Katie M. Ellison et al. · American Journal of Clinical Nutrition · 2025

Why this rating

RCT design, clear null results for the secondary comparison.

Source

Adaptive dietary and exercise strategies for weight loss in Adults with Prediabetes Trial (ADAPT): a sequential multiple assignment randomized trial

Katie M. Ellison et al. · American Journal of Clinical Nutrition · 2025

rct · n=83Cited 1×
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