Hormonal

Rotating night shift work (defined as ≥3 night shifts per month) is associated with a statistically significant but small absolute increase in coronary heart disease (CHD) risk in women, with risk increasing in a duration-dependent manner (≥5 years exposure).

For women in rotating night shift roles (≥3 nights/month), long-term exposure (≥5 years) is linked to a modestly higher risk of heart disease. The risk appears to be most relevant during active exposure and decreases after stopping shift work. Regular cardiovascular monitoring is advisable for those with this work history, particularly if they have other risk factors like obesity.