Research
Hormonal
Fibrosis and inflammation significantly confound steatosis biomarkers, causing them to yield higher values in patients with advanced fibrosis or NASH even when the amount of liver fat is similar.
If your steatosis biomarker score is high, do not assume you have severe fatty liver. It may be elevated due to liver inflammation or scarring (fibrosis). These markers are not specific to fat alone.
GoodRefutesHIGH confidence
Both fibrosis and inflammation significantly confounded the association between steatosis biomarkers and steatosis.
Why this rating
Robust statistical adjustment (multiple linear regression) showing independent correlation with fibrosis/inflammation.
Source
Performance and limitations of steatosis biomarkers in patients with nonalcoholic fatty liver disease
Larysa Fedchuk et al. · Alimentary Pharmacology & Therapeutics · 2014
DOI 10.1111/apt.12963
cohort · n=324Cited 509×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Steatosis biomarkers (FLI, NAFLD-LFS, HSI, VAI, TyG) are strongly correlated with insulin resistance (HOMA-IR) independently of the actual amount of liver fat.Good
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