Hormonal
Oral butyrate supplementation prevents high-fat-diet-induced obesity and reverses established insulin resistance in murine models by reducing adiposity and improving insulin sensitivity.
While human trials are less extensive than animal studies, increasing butyrate production through resistant starches (like cooled potatoes or legumes) or direct supplementation may help manage body weight and insulin sensitivity, especially when combined with a diet high in fat. Consult a doctor before starting supplementation.
Indeed, oral and dietary supplementation of butyrate alone has been shown to prevent high fat-diet induced obesity and insulin resistance.
Why this rating
Based on multiple murine studies cited, but human clinical data is limited in this review.
Source
Short Chain Fatty Acids in the Colon and Peripheral Tissues: A Focus on Butyrate, Colon Cancer, Obesity and Insulin Resistance
Sean M. McNabney et al. · Nutrients · 2017
DOI 10.3390/nu9121348
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