Research
Hormonal
AMPK is required for exercise-induced mitophagy, as blocking AMPK activity abolishes the increase in mitophagic markers (pure red puncta) following exercise.
If your AMPK pathway is impaired (e.g., due to metabolic disease or specific genetic factors), your body may fail to perform the necessary cleanup of damaged mitochondria after exercise, potentially blunting long-term health benefits.
GoodSupportsHIGH confidence
The increase in MitoTimer pure red puncta 6 h post-exercise observed in WT mice was completely abolished in dnTG mice... demonstrating that exercise-induced mitophagy is blocked in dnTG mice.
Why this rating
Strong evidence from dominant-negative AMPK transgenic mice showing complete abolition of the mitophagy signal.
Source
Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy
Rhianna C. Laker et al. · Nature Communications · 2017
DOI 10.1038/s41467-017-00520-9
mechanism_onlyCited 505×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Acute exercise induces mitophagy in skeletal muscle via an AMPK-dependent phosphorylation of Ulk1 at Serine 555, which is required for targeting damaged mitochondria to lysosomes.Good
- Ulk1 is required for the targeting of mitochondria to lysosomes during exercise-induced mitophagy, but is not required for lysosomal biogenesis itself.Good
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