Hormonal
Postdevelopmental inactivation of evolutionarily conserved essential genes (via RNAi) extends adult lifespan in C. elegans, with some inactivations extending lifespan as robustly as the strongest known regulators like daf-2.
This study in worms shows that turning down certain essential genes after adulthood can significantly extend lifespan, often through insulin-like signaling pathways. While direct application to humans is not possible, it highlights that aging is a regulated biological process influenced by conserved genetic pathways, suggesting that interventions targeting these pathways (like insulin signaling) might be viable strategies for longevity.
We screened 2,700 genes essential for Caenorhabditis elegans development and identified 64 genes that extend lifespan when inactivated postdevelopmentally. Many of these essential gene inactivations extend lifespan as much as the strongest known regulators of aging.
Why this rating
Large-scale screen (2,700 genes) with replication and validation in a model organism (C. elegans), but results are specific to this organism and genetic context.
Source
Lifespan Regulation by Evolutionarily Conserved Genes Essential for Viability
Sean P. Curran et al. · PLoS Genetics · 2007
DOI 10.1371/journal.pgen.0030056
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