Hormonal
Administration of the plasma protein encoded by the obese gene (leptin) reduces body weight in genetically obese (ob/ob) mice by restoring energy balance.
This foundational research identifies leptin as a key hormone regulating body weight. For individuals with specific genetic leptin deficiencies, leptin therapy can be effective. For the general population, this highlights the importance of hormonal balance in weight management, though direct leptin supplementation is not a standard or effective treatment for common obesity due to leptin resistance.
Administration of the plasma protein encoded by the obese gene (leptin) reduces body weight in genetically obese (ob/ob) mice by restoring energy balance.
Why this rating
High-quality experimental data in a well-defined genetic model, though not human clinical data.
Source
Weight-Reducing Effects of the Plasma Protein Encoded by the <i>obese</i> Gene
Jeffrey L. Halaas et al. · Science · 1995
DOI 10.1126/science.7624777
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