Research
Macro partitioning
MCP-1/CCR2 and RANTES/CCR5 chemokine signaling pathways are critical for macrophage recruitment and the progression of hepatic steatosis to NASH.
Chemokines like MCP-1 and RANTES recruit inflammatory immune cells to the liver, worsening NAFLD. Blocking these pathways (currently experimental) or reducing their expression through diet/lifestyle may help mitigate liver inflammation.
GoodSupportsHIGH confidence
Thus, collectively, MCP-1-CCR2 signaling is central to the progression of hepatic steatosis to NASH.
Why this rating
Supported by genetic deletion studies in mice and human serum level correlations.
Source
Nonalcoholic Fatty Liver Disease and Insulin Resistance: New Insights and Potential New Treatments
Hironori Kitade et al. · Nutrients · 2017
narrative_reviewCited 496×
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