Hormonal

Colonization of germfree mice with a human-derived microbiome (HBF) significantly alters host lipid metabolism by increasing ileal tauro-conjugated bile acids, which leads to reduced plasma lipoproteins but increased hepatic triglyceride storage and glutathione depletion.

Your gut bacteria directly influence how your body handles fats. Introducing specific microbial communities can shift your bile acid profile, which in turn affects how much fat is stored in your liver versus circulating in your blood. While this study used mice, it highlights that microbiome composition is a key driver of lipid metabolism, not just diet alone.