Hormonal
Liraglutide monotherapy significantly improves glycemic control (reducing A1C and fasting plasma glucose) and lowers body weight in patients with type 2 diabetes without causing hypoglycemia.
For patients with Type 2 Diabetes, Liraglutide is a once-daily injection that effectively lowers blood sugar (A1C) and promotes weight loss without the risk of dangerous low blood sugar levels. While gastrointestinal side effects like nausea are common initially, they tend to subside, and the clinical benefits for glycemic control and weight management are significant.
The present study demonstrated sustained effect of the long-acting GLP-1 analog liraglutide on glycemic control in patients with type 2 diabetes without any major or minor hypoglycemic episodes... Furthermore, in spite of improved glycemic control, which is often associated with an increase in body weight, a dose-dependent decrease in body weight was seen.
Why this rating
Double-blind, randomized, placebo-controlled trial with statistically significant results (P < 0.0001) for primary endpoints.
Source
Liraglutide, a Long-Acting Human Glucagon-Like Peptide-1 Analog, Given as Monotherapy Significantly Improves Glycemic Control and Lowers Body Weight Without Risk of Hypoglycemia in Patients With Type 2 Diabetes
Tina Vilsbøll et al. · Diabetes Care · 2007
DOI 10.2337/dc06-2593
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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