Research
Hormonal
Pharmacological interventions targeting aging pathways (e.g., rapamycin, metformin, resveratrol) show potential to decelerate vascular aging but are limited by side effects and are not yet recommended for healthy individuals.
Do not use anti-aging drugs like rapamycin or metformin for healthy aging without medical supervision. Focus on lifestyle changes first, as they are safer and more effective. Pharmacological options are currently reserved for specific medical conditions.
ModerateQualifiesMEDIUM confidence
The use of pharmacological approaches to delay aging in healthy individuals is still controversial due to their potential long-term side effects, which may exceed the benefits.
Why this rating
Based on preclinical models and some clinical trials, but long-term effects in healthy humans are unknown.
Source
Biological Versus Chronological Aging
Magda R. Hamczyk et al. · Journal of the American College of Cardiology · 2020
DOI 10.1016/j.jacc.2019.11.062
narrative_reviewCited 470×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Biological age biomarkers (e.g., arterial stiffness, epigenetic clocks) provide a more accurate assessment of cardiovascular risk and mortality than chronological age alone.Good
- Lifestyle interventions, specifically physical activity and healthy dietary patterns (Mediterranean/DASH), decelerate biological vascular aging and improve vascular health measures.Good
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