Hormonal
Dietary flavonoids exert anti-obesity and anti-diabetic effects by modulating multiple molecular targets, including the activation of AMPK and GLUT4 translocation to improve glucose uptake, and the inhibition of inflammatory cytokines (TNF-α, IL-6) and lipid synthesis enzymes (SREBP-1c, HMG-CoA) to reduce fat accumulation.
Incorporate flavonoid-rich foods like berries, tea, citrus fruits, and soy into your diet. These compounds may help manage blood sugar and weight by improving insulin sensitivity and reducing inflammation, though specific dosages and long-term human effects require more clinical research.
Flavonoids regulate carbohydrate digestion, adipose deposition, insulin release, and glucose uptake in insulin-responsive tissues through numerous cell-signaling pathways... Flavonoids showed anti-obesity and anti-diabetic effects by activating or inhibiting different cytokines, enzymes, and metabolites to prevent inflammation, oxidative stress, and metabolism to protect against obesity and diabetes.
Why this rating
The paper is a review summarizing in vitro and in vivo animal studies; it does not present new human clinical trial data, limiting direct translational evidence quality.
Source
Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids
Mohammed Kawser Hossain et al. · International Journal of Molecular Sciences · 2016
DOI 10.3390/ijms17040569
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