Hormonal
Administering tirzepatide (10 or 15 mg once weekly) to adults with overweight or obesity who have already achieved ≥5% weight loss through intensive lifestyle intervention results in substantial additional weight reduction (mean -18.4% from randomization) and prevents weight regain compared to placebo.
If you have successfully lost at least 5% of your body weight through diet and exercise, adding once-weekly tirzepatide (10 or 15 mg) can help you lose an additional ~18% of your body weight and prevent the typical weight regain seen after lifestyle interventions. This approach is particularly relevant if you have obesity-related complications, as it offers superior cardiometabolic benefits compared to lifestyle changes alone.
Tirzepatide provided substantial additional reduction in body weight in participants who had achieved ≥5.0% weight reduction with intensive lifestyle intervention... The coprimary endpoint of additional mean per cent weight change from randomization to week 72 was met with changes of −18.4%... with tirzepatide and 2.5%... with placebo
Why this rating
Phase 3, double-blind, placebo-controlled randomized trial with a large sample size (n=579) and statistically significant results (P < 0.001).
Source
Tirzepatide after intensive lifestyle intervention in adults with overweight or obesity: the SURMOUNT-3 phase 3 trial
Thomas A. Wadden et al. · Nature Medicine · 2023
DOI 10.1038/s41591-023-02597-w
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