Research
Hormonal
Senescent cells secrete a complex, heterogeneous proteome (SASP) that includes specific proteins (GDF15, STC1, SERPINs) which correlate with human aging and serve as potential plasma biomarkers for cellular senescence burden.
This research identifies specific proteins (GDF15, STC1, SERPINs) secreted by senescent cells that correlate with aging in human blood. While not yet a commercial test, these markers offer a potential way to measure 'senescent burden' in the future, linking cellular aging to systemic health.
GoodSupportsHIGH confidence
Our findings will facilitate the identification of proteins characteristic of senescence-associated phenotypes and catalog potential senescence biomarkers to assess the burden, originating stimulus, and tissue of origin of senescent cells in vivo.
Why this rating
Large-scale proteomic atlas with validation in human cohort (BLSA), but observational correlation rather than causal intervention.
Source
A proteomic atlas of senescence-associated secretomes for aging biomarker development
Nathan Basisty et al. · PLoS Biology · 2020
DOI 10.1371/journal.pbio.3000599
mechanism_onlyCited 1,276×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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