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Autophagy in the hypothalamus regulates food intake by modulating the expression of AgRP neurons in response to starvation and free fatty acid levels.

Fasting triggers a brain-based hunger signal (AgRP) that is dependent on the brain's ability to recycle stored fat (lipophagy). If you are trying to fast, ensuring your brain's autophagy is functioning may help manage hunger cues. However, this is a complex neural process and not something that can be directly 'controlled' by diet alone.

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Lipophagy-generated hypothalamic FFA directly regulate the increase in orexigenic AgRP expression that occurs in AgRP hypothalamic neurons in response to starvation or to exposure to extracellular FFA.
Rajat Singh et al. · International Journal of Cell Biology · 2012

Why this rating

Based on mouse knockout studies showing reduced food intake and body weight when autophagy is blocked in AgRP neurons.

Source

Lipophagy: Connecting Autophagy and Lipid Metabolism

Rajat Singh et al. · International Journal of Cell Biology · 2012

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