Research
Hormonal
Hepatic insulin resistance, characterized by failure to suppress hepatic glucose production (gluconeogenesis and glycogenolysis), is a major feature of type 2 diabetes pathophysiology.
Managing fasting blood glucose often requires addressing hepatic glucose output, which can be influenced by weight loss and specific medications that target liver insulin sensitivity.
StrongSupportsHIGH confidence
Hepatic insulin resistance has been characterized by a reduction of insulin-stimulated signal transduction pathways for hepatic glucose production... Liver insulin resistance is a major feature of type 2 diabetes pathophysiology
Why this rating
Well-established in the literature reviewed.
Source
Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease
Alexandra Chadt et al. · Pflügers Archiv - European Journal of Physiology · 2020
DOI 10.1007/s00424-020-02417-x
narrative_reviewCited 487×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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