Research
Hormonal
The metabolic effects of central ghrelin on adipose tissue are mediated by the sympathetic nervous system, as evidenced by the lack of metabolic response in mice lacking beta-adrenergic receptors.
The brain's command to store fat via ghrelin is sent through the sympathetic nervous system. Disrupting this pathway (as seen in specific genetic knockouts) blocks the fat-storage signal, highlighting the nervous system's role in hormonal fat regulation.
GoodSupportsHIGH confidence
These ghrelin effects were dose dependent, occurred independently from ghrelin-induced hyperphagia, and seemed to be mediated by the sympathetic nervous system.
Why this rating
Strong mechanistic evidence using knockout models (TKO mice).
Source
Ghrelin action in the brain controls adipocyte metabolism
C. Theander-Carrillo · Journal of Clinical Investigation · 2006
DOI 10.1172/jci25811
mechanism_onlyCited 459×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Central administration of ghrelin directly regulates adipocyte metabolism by increasing glucose utilization and promoting fat storage in white adipose tissue (WAT) while decreasing thermogenesis in brown adipose tissue (BAT), independent of increased food intake.Good
- Endogenous ghrelin is physiologically relevant for regulating lipid-metabolizing enzymes in white adipose tissue, as ghrelin-deficient mice exhibit decreased expression of fat-storage enzymes (LPL, SCD1).Good
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