Research
Hormonal
Myostatin inhibition is a potential therapeutic target for muscle atrophy, but current clinical trials have largely failed to increase muscle strength in patients.
Do not expect myostatin-inhibiting supplements or drugs to build muscle strength currently. Clinical trials have failed to show benefits. Focus on resistance training, which naturally modulates these pathways effectively.
GoodQualifiesMEDIUM confidence
Indeed, since the early 2000s, there have been numerous agents tested as potential myostatin antagonists... albeit with none found to be clinically successful in increasing muscle strength in muscle dystrophy patients (330), or, studies had to be discontinued for safety reasons (33).
Why this rating
Based on review of multiple clinical trials.
Source
Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake
Karla E. Merz et al. · Comprehensive physiology · 2020
DOI 10.1002/cphy.c190029
narrative_reviewCited 485×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Skeletal muscle is responsible for over 80% of postprandial glucose uptake, making it the primary driver of whole-body insulin resistance and glucose homeostasis.Strong
- Exercise and insulin stimulate glucose uptake via distinct, independent signaling pathways that both converge on GLUT4 translocation.Strong
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