Hormonal
Maintaining elevated free fatty acid (FFA) levels during hyperinsulinemia significantly inhibits skeletal muscle glucose storage (glycogen synthesis) and reduces glycogen synthase fractional velocity, representing the primary mechanism of FFA-induced insulin resistance in muscle.
When your insulin is high (e.g., after a high-carb meal), your body's ability to store glucose as glycogen in muscles is significantly reduced if free fatty acids are also circulating. To maximize muscle glycogen storage, minimize fat intake in meals containing carbohydrates, or separate high-fat and high-carb meals to allow distinct metabolic phases.
The greatest effect of FFA replacement was reduced muscle glucose storage (0.36±0.20 vs 1.24±0.25 ,umol/min per 100 ml, P < 0.01), accompanied by decreased GS fractional velocity (0.129±0.26 vs 0.169±0.033, P < 0.01).
Why this rating
Randomized crossover design with direct muscle biopsies and leg balance techniques in healthy humans, though limited to short-term acute effects.
Source
Interaction between glucose and free fatty acid metabolism in human skeletal muscle.
David E. Kelley et al. · Journal of Clinical Investigation · 1993
DOI 10.1172/jci116603
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