Hormonal
In recently postmenopausal women, 4 years of oral conjugated equine estrogens (o-CEE) combined with micronized progesterone improves depression and anxiety symptoms, whereas transdermal estradiol (t-E2) provides no mood benefit compared to placebo.
If you are a recently postmenopausal woman considering hormone therapy for mood symptoms, oral conjugated equine estrogens (CEE) combined with progesterone may help reduce depression and anxiety over 4 years. Transdermal estradiol patches did not show these mood benefits compared to placebo. Hormone therapy did not improve cognition in this study.
For mood, model estimates indicated that women treated with o-CEE showed improvements in depression and anxiety symptoms over the 48 mo of treatment, compared to women on placebo... Mood outcomes for women randomized to t-E2 were similar to those for women on placebo.
Why this rating
Randomized, double-blind, placebo-controlled trial (RCT) with a large sample size (n=693) and long duration (4 years).
Source
Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women: Findings from the Randomized, Controlled KEEPS–Cognitive and Affective Study
Carey E. Gleason et al. · PLoS Medicine · 2015
DOI 10.1371/journal.pmed.1001833
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