Research
Hormonal
Obesity causes hypertension through multiple mechanisms including sympathetic nervous system activation, renin-angiotensin system (RAS) overexpression in adipose tissue, and renal sodium retention.
If you have obesity, your risk for high blood pressure is significantly increased due to biological mechanisms involving your nervous system and hormones. Managing your weight through diet and exercise can help mitigate these risks.
GoodSupportsHIGH confidence
Activation of the sympathetic nervous system (SNS), the amount of intra-abdominal and intra-vascular fat, sodium retention leading to increase in renal reabsorption, and the renin-angiotensin system, are considered to have important functions in the pathogenesis of obesity-related hypertension
Why this rating
The paper is a review citing multiple observational and experimental studies, but lacks a single definitive clinical trial.
Source
Obesity and hypertension
Shu-Zhong Jiang et al. · Experimental and Therapeutic Medicine · 2016
DOI 10.3892/etm.2016.3667
narrative_reviewCited 450×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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