Macro partitioning
Orlistat (60-120 mg three times daily) combined with a hypocaloric diet produces significantly greater weight loss and improved cardiovascular risk factors compared to diet and placebo alone.
Take orlistat (60mg or 120mg) with your three main meals if you consume fat. Combine this with a calorie-controlled diet for the first year, then switch to a maintenance diet. Expect significant weight loss and improved cholesterol/blood pressure, but be prepared for mild, temporary gastrointestinal side effects if you eat too much fat.
Orlistat-treated patients lost significantly more weight (p < 0.001) than placebo-treated patients after Year 1 (6.6%, 8.6%, and 9.7% for the placebo, and orlistat 60 mg and 120 mg groups, respectively).
Why this rating
Randomized, double-blind, placebo-controlled multicenter study with 729 patients over 2 years.
Source
Weight Loss, Weight Maintenance, and Improved Cardiovascular Risk Factors after 2 Years Treatment with Orlistat for Obesity
Stephan Rössner et al. · Obesity Research · 2000
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →