Research

Hormonal

During midlife, women experience a cumulative 6-year increase in fat mass of 3.4 kg and a decrease in skeletal muscle mass of 0.23 kg, driven by both chronological aging and ovarian aging (menopause).

If you are a woman in your 40s or 50s, expect your body composition to shift: you will likely gain about 3.4 kg of fat and lose 0.23 kg of muscle over 6 years, largely due to hormonal changes. This is not just 'getting older' but specifically linked to ovarian aging. To counteract this, prioritize resistance training to preserve muscle mass and manage caloric intake to limit fat gain, as these changes are driven by hormonal shifts (FSH) that affect how your body stores fat and muscle.

GoodSupportsHIGH confidence
There was an absolute cumulative 6-yr increase in fat mass of 3.4 kg and a 6-yr decrease in skeletal muscle mass of approximately 0.23 kg... Both time (chronological aging) and ovarian aging contributed to substantial changes in body composition (fat and skeletal muscle mass) and waist circumference.
MaryFran R. Sowers et al. · The Journal of Clinical Endocrinology & Metabolism · 2006

Why this rating

Longitudinal study with 543 participants and 7 annual measures, though it is observational and not an intervention trial.

Source

Changes in Body Composition in Women over Six Years at Midlife: Ovarian and Chronological Aging

MaryFran R. Sowers et al. · The Journal of Clinical Endocrinology & Metabolism · 2006

DOI 10.1210/jc.2006-1393

cohort · n=543Cited 477×
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DOI resolved against Crossref · corpus check 2026-06-10

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