Hormonal
Ingestion of short-chain fatty acids (SCFAs), specifically propionate and butyrate, stimulates PYY gene expression and secretion in human enteroendocrine cells via histone deacetylase (HDAC) inhibition, thereby increasing plasma PYY levels.
To maximize your natural PYY production (a hormone that helps you feel full), focus on consuming high-fiber foods that your gut bacteria can ferment into short-chain fatty acids like butyrate and propionate. This process naturally stimulates your gut hormones to regulate appetite, a mechanism that works specifically in humans.
In summary, this study revealed a strong regulation of PYY production by SCFA that was evident in humans but not mice, and suggests that high fibre diets elevate plasma concentrations of the anorexigenic hormone PYY, both by targeting gene expression and hormone secretion.
Why this rating
High-quality in vitro and ex vivo human tissue data with rigorous mechanistic dissection (CRISPR, agonists, inhibitors), though not a clinical trial.
Source
SCFAs strongly stimulate PYY production in human enteroendocrine cells
Pierre Larraufie et al. · Scientific Reports · 2018
DOI 10.1038/s41598-017-18259-0
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