Hormonal
Endogenous GLP-1 signaling in the VTA and NAc core is physiologically necessary to regulate high-fat diet intake, as blocking these receptors leads to increased consumption.
Your brain naturally produces GLP-1 to help keep you from overeating high-fat foods. This study shows that if you block this natural signaling in the reward centers of your brain, you will eat more high-fat food. This suggests that maintaining healthy endogenous GLP-1 signaling (through diet and lifestyle) is important for regulating cravings for palatable foods.
blockade of endogenous GLP-1R signaling in the VTA and NAc core resulted in a significant increase in food intake, establishing a physiological relevance for GLP-1 signaling in the MRS.
Why this rating
Strong pharmacological evidence using an antagonist (Exendin-9) to prove physiological necessity.
Source
GLP-1 Neurons in the Nucleus of the Solitary Tract Project Directly to the Ventral Tegmental Area and Nucleus Accumbens to Control for Food Intake
Amber L. Alhadeff et al. · Endocrinology · 2011
DOI 10.1210/en.2011-1443
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