Hormonal
In healthy men, restricting dietary phosphorus to low-normal levels (625 mg/d) significantly decreases serum FGF-23 concentrations compared to control (1500 mg/d) or high-normal (2300 mg/d) intakes, while increasing 1,25(OH)2D levels.
For healthy men, maintaining a normal dietary phosphorus intake (around 1500 mg/day) is sufficient to regulate FGF-23 and vitamin D metabolism. Extreme restriction (625 mg/day) lowers FGF-23 and raises active Vitamin D, but this is a physiological response to restriction, not necessarily a health benefit. There is no need to restrict phosphorus in healthy individuals.
When dietary phosphorus was restricted to 625 mg/d, serum FGF-23 concentrations decreased to 19.6 (cid:2) 7.0 pg/ml, a value significantly lower than that during the control or supplemented phosphorus periods (P (cid:3) 0.001).
Why this rating
Randomized controlled trial with constant diet and inpatient monitoring, though small sample size (n=13).
Source
Dietary Phosphorus Regulates Serum Fibroblast Growth Factor-23 Concentrations in Healthy Men
Diana M. Antoniucci et al. · The Journal of Clinical Endocrinology & Metabolism · 2006
DOI 10.1210/jc.2006-0021
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