Research
Hormonal
High-dose resveratrol supplementation (1500 mg/day) for 4 weeks produces no significant improvement in insulin sensitivity, substrate metabolism, blood pressure, or body composition in obese men.
Taking 1500 mg of resveratrol daily for a month will not improve your insulin sensitivity, lower your blood pressure, or change your body composition if you are obese. The supplement does not work for these metabolic goals in humans, despite what animal studies suggest.
GoodRefutesHIGH confidence
Insulin sensitivity, the primary outcome measure, deteriorated insignificantly in both groups... Resveratrol supplementation also had no effect on blood pressure; resting energy expenditure; oxidation rates of lipid; ectopic or visceral fat content; or inflammatory and metabolic biomarkers.
Why this rating
Randomized, placebo-controlled, double-blinded clinical trial with gold-standard measurement (hyperinsulinemic euglycemic clamp).
Source
High-Dose Resveratrol Supplementation in Obese Men
Morten Møller Poulsen et al. · Diabetes · 2012
DOI 10.2337/db12-0975
rct · n=24Cited 442×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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