Hormonal

Doubling basal insulin levels (low-dose infusion) is sufficient to block free fatty acid release from adipose tissue but is often insufficient to block amino acid release from muscle, indicating different sensitivity thresholds for these metabolic pathways.

Low levels of insulin are enough to stop your fat cells from releasing fatty acids, but they are often not enough to stop your muscles from releasing amino acids. To significantly reduce muscle protein breakdown, you likely need higher insulin levels or other strategies, as low-level insulin elevation primarily targets fat metabolism.