Research
Hormonal
Metformin reduces all-cause mortality by 36% and heart attack incidence by 39% in overweight patients with newly diagnosed type 2 diabetes without established cardiovascular disease.
If you have recently been diagnosed with Type 2 Diabetes and are overweight, metformin is likely your first medication. It not only helps control blood sugar but has been shown to significantly reduce the risk of heart attacks and death.
GoodSupportsHIGH confidence
The UK Prospective Diabetes Study (UKPDS 34) found that metformin therapy reduced all-cause mortality by 36% and heart attack incidence by 39% among overweight patients with newly diagnosed T2DM [45].
Why this rating
Based on the UKPDS, a landmark trial.
Source
Cardiovascular disease in type 2 diabetes mellitus: progress toward personalized management
Chengxu Ma et al. · Cardiovascular Diabetology · 2022
DOI 10.1186/s12933-022-01516-6
narrative_reviewCited 439×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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