Hormonal

In healthy elderly individuals, age-associated deterioration in glucose tolerance is driven by decreased insulin secretion and action, where the severity of insulin resistance is determined by body fatness rather than chronological age itself.

For older adults, maintaining low visceral fat and high aerobic fitness is more critical for glucose tolerance than chronological age. While beta-cell function declines with age, managing body composition can mitigate insulin resistance. Focus on preserving muscle mass and reducing visceral adiposity rather than accepting metabolic decline as inevitable.