Research
Hormonal
DPP4 inhibitors exert effects beyond incretin regulation by interacting with non-incretin substrates such as SDF-1, NPY, PYY, and Substance P, potentially influencing inflammation, angiogenesis, and appetite.
DPP4 inhibitors may have additional benefits beyond lowering blood sugar, potentially affecting inflammation, appetite, and blood vessel health by preserving other important peptides in the body.
ModerateQualifiesMEDIUM confidence
The list of DPP4 substrates mentioned here is not fully complete and aims to highlight the importance of DPP4 in T2DM also beyond its well-known incretin effect.
Why this rating
The paper reviews these interactions but notes 'proof that PACAP also plays a role in humans is lacking so far' for some substrates.
Source
DPP4 in diabetes
Diana Röhrborn · Frontiers in Immunology · 2015
DOI 10.3389/fimmu.2015.00386
narrative_reviewCited 434×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- DPP4 inhibitors (gliptins) treat type 2 diabetes by blocking the enzymatic degradation of incretin hormones (GLP-1 and GIP), thereby prolonging their half-life and enhancing glucose-dependent insulin secretion.Good
- Circulating soluble DPP4 (sDPP4) acts as an adipokine that contributes to vascular dysfunction and cardiovascular disease risk in obese and diabetic individuals.Moderate
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