Research
Macro partitioning
Higher intake of trans-fatty acids (TFA) is associated with increased total mortality and cause-specific mortality (particularly cardiovascular and neurodegenerative diseases).
Avoid industrial trans fats, which are found in partially hydrogenated oils used in some fried foods and baked goods. Higher intake of trans fats is linked to a 13% higher risk of total mortality and a 20% higher risk of cardiovascular disease mortality. Check labels for 'partially hydrogenated oils' and minimize consumption.
StrongSupportsHIGH confidence
For TFA intake, a significant positive association with total mortality was observed (HR comparing extreme quintiles, 1.13; 95% CI, 1.07-1.18; P < .001 for trend)... TFA intake was associated with a 20% higher CVD mortality across quintiles (HR, 1.20; 95% CI, 1.08-1.33; P < .001 for trend).
Why this rating
Large prospective cohort studies with long follow-up and rigorous adjustment.
Source
Association of Specific Dietary Fats With Total and Cause-Specific Mortality
Dong D. Wang et al. · JAMA Internal Medicine · 2016
DOI 10.1001/jamainternmed.2016.2417
cohort · n=126233Cited 433×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Replacing 5% of total energy intake from saturated fats with polyunsaturated fatty acids (PUFA) or monounsaturated fatty acids (MUFA) is associated with a significant reduction in total mortality.Strong
- Higher intake of polyunsaturated fatty acids (PUFA), particularly linoleic acid (omega-6), and monounsaturated fatty acids (MUFA) is associated with lower total mortality and cause-specific mortality.Strong
Related findings · Macro partitioning
- Total daily protein intake of 1.6 g/kg/day is sufficient for maximizing resistance training-induced muscle gains, with an upper confidence interval of 2.2 g/kg/day.Strong
- Resistance exercise training combined with sufficient dietary protein intake acts synergistically to maximize skeletal muscle hypertrophy, with protein intake saturating around 1.6 g/kg/day for general populations and potentially requiring 2.0-2.2 g/kg/day for resistance-trained individuals.Strong
- Trans fats should be completely eliminated from the diet, as they increase LDL cholesterol, decrease HDL cholesterol, and are directly associated with increased coronary risk.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →