Macro partitioning
In healthy young adults, higher carbohydrate intake is associated with increased soluble leptin receptor (sOB-R) concentrations, while higher dietary fat intake is associated with decreased sOB-R, independent of total energy intake and body fat mass.
If you are healthy and maintaining your weight, the type of carbohydrates and fats you eat may influence your soluble leptin receptor levels. Specifically, higher carbohydrate intake is linked to higher sOB-R, while higher fat intake is linked to lower sOB-R. This suggests that macronutrient balance matters for hormonal regulation beyond just total calories.
Multiple regression analysis models controlling for gender, body fat, and total energy intake demonstrated that sOB-R is positively associated with energy intake from carbohydrates and negatively with energy intake from dietary fat
Why this rating
Cross-sectional observational study with rigorous control for confounders (gender, body fat, total energy), but causality cannot be established.
Source
Body Fat Mass and Macronutrient Intake in Relation to Circulating Soluble Leptin Receptor, Free Leptin Index, Adiponectin, and Resistin Concentrations in Healthy Humans
Mary Yannakoulia et al. · The Journal of Clinical Endocrinology & Metabolism · 2003
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