Hormonal
Supplementation with 20 g/day of inulin-propionate ester (IPE) or inulin for 42 days improves insulin sensitivity in adults with overweight and obesity compared to cellulose.
If you have overweight or obesity, adding 20 grams daily of either inulin or inulin-propionate ester (IPE) to your diet for about six weeks can improve how your body handles insulin compared to eating non-fermentable fiber. You can split the dose into two 10-gram servings mixed into your food. While both work similarly for insulin sensitivity, IPE specifically reduces inflammatory markers, whereas inulin changes gut bacteria differently. Consult your doctor before starting, especially if you have existing digestive conditions.
Both iPe and inulin supplementation improved insulin resistance compared with cellulose supplementation, measured by homeostatic model assessment 2 (mean±SeM 1.23±0.17 iPe vs 1.59±0.17 cellulose, p=0.001; 1.17±0.15 inulin vs 1.59±0.17 cellulose, p=0.009)...
Why this rating
Randomized, double-blind, placebo-controlled, cross-over trial with 12 participants.
Source
Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut microbiota, plasma metabolome and systemic inflammatory responses: a randomised cross-over trial
Edward S. Chambers et al. · Gut · 2019
DOI 10.1136/gutjnl-2019-318424
More from this paper
- Inulin-propionate ester (IPE) supplementation reduces systemic proinflammatory interleukin-8 (IL-8) levels in adults with overweight and obesity, an effect not observed with inulin alone.Good
- Inulin supplementation promotes a bifidogenic effect (increased Bifidobacterium) and alters gut bacterial composition at the class and order levels, whereas IPE primarily affects bacterial populations at the species level.Good
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