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One night of total sleep deprivation prevents the physiological morning decrease in cerebrospinal fluid (CSF) β-amyloid 42 (Aβ42) levels observed during normal sleep in healthy middle-aged men.
Prioritize getting a full night's sleep. This study shows that missing sleep prevents your brain from clearing amyloid proteins, a key factor in Alzheimer's disease. While this study used total sleep deprivation, the mechanism suggests that even partial sleep restriction may impair this clearance process.
GoodSupportsHIGH confidence
A night of unrestricted sleep led to a 6% decrease in Aβ42 levels... whereas sleep deprivation counteracted this decrease.
Why this rating
Randomized clinical trial with a small sample size (n=26) but rigorous CSF sampling methodology.
Source
Effect of 1 Night of Total Sleep Deprivation on Cerebrospinal Fluid β-Amyloid 42 in Healthy Middle-Aged Men
Sharon Ooms et al. · JAMA Neurology · 2014
rct · n=26Cited 424×
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