Research
Hormonal
Glucocorticoids (corticosteroids) act as a primary synchronizing signal from the central SCN to peripheral clocks, particularly in the liver, regulating up to 60% of the hepatic transcriptome.
Cortisol rhythms help synchronize your liver's metabolism to the day. Disrupting this rhythm (e.g., through stress or irregular sleep) may impair liver function and detoxification pathways.
StrongSupportsVERY_HIGH confidence
A single treatment of SCN-ablated mice with dexamethasone can activate ca. 60% of the liver circadian transcriptome, including core clock and clock-controlled genes that carry GC-response elements (GREs).
Why this rating
Direct experimental evidence from gene expression profiling in mouse models.
Source
Circadian clocks: regulators of endocrine and metabolic rhythms
Michael H. Hastings et al. · Journal of Endocrinology · 2007
DOI 10.1677/joe-07-0378
narrative_reviewCited 422×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Disruption of circadian rhythms (e.g., via shift work or jet lag) impairs health by desynchronizing peripheral tissue clocks from the central SCN pacemaker, leading to metabolic and endocrine dysfunction.Good
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