Hormonal
Acquired obesity, independent of genetic factors, causes deleterious alterations in serum lipid metabolism characterized by increased lysophosphatidylcholines (LPCs) and decreased ether phospholipids, which facilitate inflammation, atherogenesis, and insulin resistance.
Your lipid profile is not fixed by your DNA. Gaining weight triggers specific chemical changes in your blood (increased LPCs, decreased protective ether phospholipids) that promote inflammation and insulin resistance. Losing weight or preventing weight gain can mitigate these specific risks, regardless of your genetic background.
Our results show that obesity, already in its early stages and independent of genetic influences, is associated with deleterious alterations in the lipid metabolism known to facilitate atherogenesis, inflammation and insulin resistance.
Why this rating
High-quality monozygotic twin design controls for genetic confounding, providing strong causal inference for environmental/acquired effects.
Source
Acquired Obesity Is Associated with Changes in the Serum Lipidomic Profile Independent of Genetic Effects – A Monozygotic Twin Study
Kirsi H. Pietiläinen et al. · PLoS ONE · 2007
DOI 10.1371/journal.pone.0000218
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