Hormonal
Pharmacological inhibition of DPP-4 improves glycemic control in Type 2 Diabetes by preventing the degradation of endogenous incretin hormones (GLP-1 and GIP), thereby enhancing glucose-dependent insulin secretion and suppressing glucagon.
DPP-4 inhibitors (like vildagliptin, sitagliptin) are oral medications that help your body manage blood sugar more effectively by keeping your natural 'incretin' hormones (GLP-1 and GIP) active longer. They are safe, well-tolerated, and do not typically cause low blood sugar on their own. They work best when your blood sugar is high, stimulating insulin only when needed.
DPP-4 inhibition was proposed as a novel approach to the treatment of T2DM... DPP-4 inhibitors are now an established therapy of T2DM... DPP-4 inhibition was well-tolerated in humans and was associated with significantly lower fasting and meal-related glucose concentrations.
Why this rating
Supported by multiple Phase 2/3 clinical trials, long-term efficacy studies, and regulatory approval.
Source
Physiology and Pharmacology of DPP-4 in Glucose Homeostasis and the Treatment of Type 2 Diabetes
Carolyn F. Deacon · Frontiers in Endocrinology · 2019
DOI 10.3389/fendo.2019.00080
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